The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo
Xue‐Quan Zhou, Ming Xiao, Vadde Ramu, Jonathan Hilgendorf, Xuezhao Li, Panagiota Papadopoulou, Maxime A. Siegler, Alexander Kros, Wen Sun, Sylvestre Bonnet
Abstract
also allows efficient cellular uptake in 3D tumor models. Overall, serum proteins appear to be a major element in drug design because they strongly influence the size and bioavailability of supramolecular drug aggregates and hence their efficacy in vitro and in vivo.
Topics & Concepts
ChemistryNanorodIn vivoLipophilicityPhotosensitizerSupramolecular chemistryIn vitroBiophysicsEndocytosisStereochemistryBiochemistryCellNanotechnologyMoleculeOrganic chemistryBiologyMaterials scienceBiotechnologyNanoplatforms for cancer theranosticsNanocluster Synthesis and ApplicationsClick Chemistry and Applications