Integrated approach toward absorption, distribution, metabolism, and excretion of Xiaoke pills in zebrafish based on UPLC-HRMS and DESI-MS techniques
Chunyan Zhu, Xiaojuan Jiang, Juanjuan Tian, Jiayun Chen, Chun-Yu Lin, Chong Wang, Cai Tie, Mingyu Li, Caisheng Wu
Topics & Concepts
ADMEChemistrySulfationIn vivoChromatographyPharmacologyOrbitrapZebrafishDemethylationGlucuronidationFormononetinMass spectrometryBiochemistryDaidzeinGenisteinMedicineInternal medicineIn vitroMicrosomeBiologyDNA methylationGene expressionGeneBiotechnologyZebrafish Biomedical Research ApplicationsMetabolomics and Mass Spectrometry StudiesNeuroinflammation and Neurodegeneration Mechanisms