Late-stage difluoromethylation: concepts, developments and perspective
Jeroen B. I. Sap, Claudio F. Meyer, Natan J. W. Straathof, Ndidi U. N. Iwumene, Christopher W. am Ende, Andrés A. Trabanco, Véronique Gouverneur
Abstract
H; more recently, numerous protocols have achieved X-H insertion with novel non-ozone depleting difluorocarbene reagents. All together, these advances have streamlined access to molecules of pharmaceutical relevance, and generated interest for process chemistry.
Topics & Concepts
Perspective (graphical)Computer scienceStage (stratigraphy)NanotechnologyData scienceMaterials scienceArtificial intelligenceGeologyPaleontologyFluorine in Organic ChemistryInorganic Fluorides and Related Compounds