Bone marrow mesenchymal stem cell-mediated ultrasmall gold nanoclusters and hNIS gene synergize radiotherapy for breast cancer
Lu Zhang, Benchao Zheng, Rui Guo, Ying Miao, Biao Li
Abstract
I therapy further demonstrated that the growth of triple negative breast cancer (TNBC) was controlled by BMSC-Egr1-hNIS + AuNCs group, with relative volume inhibition percentages of 56.16% (compared with the control group) and 36.20% (compared with the BMSC-Egr1-hNIS group), respectively. To summarize, we successfully prepared BMSC-Egr1-hNIS carrying GSH@AuNCs to target TNBC which could synergistically improve the efficacy of hNIS gene therapy.
Topics & Concepts
NanoclustersMesenchymal stem cellCancer researchBreast cancerBone marrowRadiation therapyMedicineOncologyCancerMaterials scienceInternal medicinePathologyNanotechnologyNanoplatforms for cancer theranosticsNanocluster Synthesis and ApplicationsGraphene and Nanomaterials Applications