Investigations into mechanism and origin of regioselectivity in the metallaphotoredox-catalyzed α-arylation of <i>N</i>-alkylbenzamides
Alexander W. Rand, Mo Chen, John Montgomery
Abstract
A mechanistic study of the α-arylation of N -alkylbenzamides catalyzed by a dual nickel/photoredox system using aryl bromides elucidates the origins of site-selectivity of the transformation and identifies the hydrogen atom transfer agent.
Topics & Concepts
ChemistryBromideDeprotonationCatalysisRegioselectivityArylStoichiometryHalidePhotochemistryAryl halideSelectivityCombinatorial chemistryMedicinal chemistryInorganic chemistryOrganic chemistryIonPalladiumAlkylRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions