Double allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers
Yingying Cai, Hao Zeng, Chuanle Zhu, Chi Liu, Guangying Liu, Huanfeng Jiang
Abstract
Synthesis of symmetric <italic>gem</italic>-difluoroalkene substituted products bearing all-carbon quaternary centers <italic>via</italic> double allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes.
Topics & Concepts
ChemistryTrifluoromethylAlkylationAllylic rearrangementQuaternary carbonTsuji–Trost reactionMedicinal chemistryOrganic chemistryCatalysisAlkylEnantioselective synthesisFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsInorganic Fluorides and Related Compounds