An All-Dielectric Metamaterial Terahertz Biosensor for Cytokine Detection
Kuo Men, Ziwei Lian, Hailing Tu, Hongbin Zhao, Qianhui Wei, Qingxi Jin, Changhui Mao, Wei Feng
Abstract
In this paper, we report an all-dielectric metamaterial terahertz biosensor, which exhibits a high Q factor of 35 at an 0.82 resonance peak. A structure with an electromagnetically induced transparency effect was designed and fabricated to perform a Mie resonance for the terahertz response. The biosensor exhibits a limit of detection of 100 pg/mL for cytokine interleukin 2 (IL-2) and a linear response for the logarithm of the concentration of IL-2 in the range of 100 pg/mL to 1 μg/mL. This study implicates an important potential for the detection of cytokines in serum and has potential application in the clinical detection of cytokine release syndrome.