Tumor redox microenvironment modulating composite hydrogels for enhanced sonodynamic therapy of colorectal cancer
Weikai Chen, Chenxi Zhang, Dagui Chen, Yinghua Li, Shunli Wu, Can Xu, Li Su, Qin Zhang
Abstract
the SDT effect. Meanwhile, the GSH inhibitor blocks the intracellular synthesis of GSH, thus leading to further enhanced SDT action. As such, composite hydrogel-mediated enhanced SDT can obviously inhibit the growth of subcutaneous colorectal cancer in mouse models. This study thus offers a tumor microenvironment modulating platform for enhanced therapy of colorectal cancer.
Topics & Concepts
Self-healing hydrogelsSonodynamic therapyTumor microenvironmentColorectal cancerRedoxCancer researchComposite numberMaterials scienceCancerMedicineChemistryReactive oxygen speciesTumor cellsInternal medicineBiochemistryComposite materialPolymer chemistryMetallurgyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesUltrasound and Hyperthermia Applications