Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, P Ralph, Jacob Coyne, Michelle K. Parkington, Jennifer DeBrecht, Lauren Ehrhardt-Humbert, Glenn Cruse, Wolfgang Bäumer, Ru‐Rong Ji, Mei‐Chuan Ko, Thierry Olivry
Abstract
β3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch.