Simultaneous and Staggered Foot-and-Mouth Disease Virus Coinfection of Cattle
Jonathan Arzt, Ian Fish, Miranda R. Bertram, George R. Smoliga, Ethan J. Hartwig, Steven J. Pauszek, Lauren Holinka-Patterson, Fayna C. Diaz-San Segundo, Tatjana Sitt, Elizabeth Rieder, Carolina Stenfeldt
Abstract
FMDV coinfections under controlled experimental conditions. Our findings confirmed that cattle could be simultaneously infected by two distinct serotypes of FMDV, with different outcomes associated with the timing of exposure to the two different viruses. Additionally, dominant interserotypic recombinant FMDVs were discovered in multiple samples from the upper respiratory tracts of five superinfected animals, emphasizing the potential importance of persistently infected FMDV carriers as sources of novel FMDV strains.
Topics & Concepts
BiologyVirologyFoot-and-mouth disease virusVirusCoinfectionSuperinfectionSubclinical infectionAphthovirusFoot-and-mouth diseaseSerotypeReassortmentDiseaseInfectious disease (medical specialty)MedicinePathologyCoronavirus disease 2019 (COVID-19)Animal Disease Management and EpidemiologyViral Infections and Immunology ResearchVector-Borne Animal Diseases