TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production
Eun‐Hye Jung, Eun Bok Baek, Eun-Ju Hong, Jee Hyun Kang, Suyoung Park, Sehee Park, Eui‐Ju Hong, Young‐Eun Cho, Je‐Won Ko, Young‐Suk Won, Hyo‐Jung Kwon
Abstract
Our findings indicate that upregulated TXNIP expression in LSECs serves a protective role in ameliorating ALD. Enhancing TXNIP expression could, therefore, be a potential therapeutic approach for ALD.
Topics & Concepts
TXNIPProinflammatory cytokineDownregulation and upregulationCancer researchNitric oxideInflammationLiver injuryBiologyEndocrinologyMedicineChemistryImmunologyOxidative stressBiochemistryThioredoxinGeneEicosanoids and Hypertension PharmacologyAlcohol Consumption and Health EffectsCancer, Hypoxia, and Metabolism