Catalytic enantioselective and site-specific Friedel–Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles
Lei Yang, Xue-Man Zhang, Juan Liao, Yanping Zhang, Zhen‐Hua Wang, Yong You, Jian‐Qiang Zhao, Wei‐Cheng Yuan
Abstract
CPA-catalyzed asymmetric Friedel–Crafts alkylation of 4-aminoindoles with ketoimines enables the synthesis of chiral C7-functionalized indoles.
Topics & Concepts
ChemistryFriedel–Crafts reactionEnantioselective synthesisAlkylationCatalysisOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisSynthesis and Catalytic Reactions