Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration
Bent Pfaffenrot, Philip Klövekorn, Michael Juchum, Roland Selig, Wolfgang Albrecht, Lars Zender, Stefan Laufer
Topics & Concepts
ChemistryKinaseProtein kinase AVemurafenibLiver regenerationBiochemistryIn vivoCell biologyRegeneration (biology)Cancer researchBiologyGeneticsMelanomaMetastatic melanomaMelanoma and MAPK PathwaysCancer Mechanisms and TherapyQuinazolinone synthesis and applications