Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.
Bridget E. Barber, Melissa Fernandez, Hardik B. Patel, Catalina Barceló, Harilal Patel, Stacey Llewellyn, Azrin N. Abd‐Rahman, Sunil Sharma, Mukul R. Jain, Ashok Ghoghari, Ilaria Di Resta, Aline Fuchs, Ioanna Deni, Tomas Yeo, Sachel Mok, David A. Fidock, Stephan Chalon, Jörg J. Möhrle, Dhruvanshu Parmar, James McCarthy, Kevinkumar Kansagra
2022LSTM Online Archive (Liverpool School of Tropical Medicine)30 citations
Topics & Concepts
MedicinePharmacokineticsPlaceboVolunteerMalariaPlasmodium falciparumAdverse effectCohortPharmacodynamicsClinical trialIncidence (geometry)Internal medicinePharmacologyImmunologyBiologyPathologyAlternative medicineOpticsAgronomyPhysicsMalaria Research and ControlDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms