Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder

Wenjun Jiang, Nan Jia, Chaowan Guo, Juan Wen, Lingqian Wu, Tomoo Ogi, Huiwen Zhang

2021Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease18 citationsDOI

Topics & Concepts

Bloom syndromeBiologyEctopic expressionPathogenesisMitochondrionWild typeMitochondrial DNAMutationGeneticsGenetic disorderMitochondrial diseaseGeneCell biologyMutantImmunologyRNAHelicaseDNA Repair MechanismsDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques