The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis
Maged W. Helmy, Asser I. Ghoneim, Mohamed Katary, Rana K. Elmahdy
Topics & Concepts
PI3K/AKT/mTOR pathwayAutophagyProtein kinase BCancer researchApoptosisColorectal cancerDiosminCell growthAngiogenesisPharmacologyMedicineChemistryCancerInternal medicinePathologyBiochemistryAlternative medicineHesperidinPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and TherapyCytokine Signaling Pathways and Interactions