Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation
Hong Xue, H. Zhou, Qiliang Lou, Putao Yuan, Zhenhua Feng, Qiao Li, Jiateng Zhang, Hongwei Xie, Yang Shen, Qingliang Ma, Shiyu Wang, Boya Zhang, Huali Ye, Jiao Cheng, Xuewu Sun, Peihua Shi
Abstract
and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
Topics & Concepts
OsteoarthritisCartilageInflammationDegeneration (medical)Cartilage damageMedicineChemistryPharmacologyArticular cartilagePathologyImmunologyAnatomyAlternative medicinePomegranate: compositions and health benefitsNatural product bioactivities and synthesisBee Products Chemical Analysis