Ir(III) Complex Dimer Nanoparticles for Photodynamic Therapy
Yingjie Liu, Dongxia Zhu, Zhigang Xie
Abstract
Iridium compounds are versatile in catalysis and photodynamic therapy. We present two Ir(III) complex dimers that can self-assemble into nanoparticles in the absence of adjuvant or surfactants. The formed nanoparticles possess a spherical morphology and robust colloidal stability and could be internalized by cancer cells. The Ir(III) complex nanoparticles have relatively strong photodynamic activity upon irradiation, which includes type I and type II reactive oxygen species. The generated reactive oxygen species could effectively induce cell death upon irradiation. This work highlights the potential of metal complexes and their nanoparticles in cancer treatment.
Topics & Concepts
Photodynamic therapyIridiumNanoparticleReactive oxygen speciesDimerCatalysisCancer therapyChemistryPorphyrinNanotechnologyMaterials sciencePhotochemistryCombinatorial chemistryCancerOrganic chemistryMedicineBiochemistryInternal medicineNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and Applications