Efficacy and safety of dupilumab in bullous pemphigoid: a retrospective multicentric study of 36 patients
Parna Moghadam, Emmanuelle Tancrède‐Bohin, Jean‐David Bouaziz, Julien Kallout, C. Bédane, É. Bégon, Isabelle Bourgault‐Villada, A. Calugareanu, O. Dereure, Fatma Jendoubi, Anne Pham‐Ledard, S. Oro, C. Picard‐Dahan, M. Viguier, T. Mahévas, M. Jachiet, Estelle Charvet, C. Cassius, M. Alexandre, C. Lepelletier
Abstract
Bullous pemphigoid (BP) is the most common autoimmune blistering disease in Europe and its treatment can be challenging. Several published cases have reported dupilumab efficiency in treatment-refractory patients. We conducted a retrospective multicentric study of 36 patients to evaluate the real-life efficiency of dupilumab in BP. Our results suggest that dupilumab, in association with high-potency topical steroids, could be rapidly effective in various clinical forms of BP and seems to be well tolerated in the elderly.