A photoacoustic Zn<sup>2+</sup> sensor based on a merocyanine/xanthene-6-ol hybrid chromophore and its ratiometric imaging in mice
Hongbao Fang, Chengjun Wang, Yuncong Chen, Zhongyan Chen, Shankun Yao, Shiping Yang, Lei Dong, Zijian Guo, Weijiang He
Abstract
<bold>HD-Zn</bold> was constructed for reversible ratiometric PA Zn<sup>2+</sup> imaging <italic>in vivo</italic>. Zn<sup>2+</sup> titration experiments together with a theoretical study suggests that Zn<sup>2+</sup> chelation-induced ICT alteration in <bold>HD-Zn</bold> is responsible for its ratiometric PA sensing ability.
Topics & Concepts
XantheneChromophorePhotoacoustic imaging in biomedicineChemistryMerocyanineTitrationChelationPhotochemistryNuclear chemistryPhysical chemistryInorganic chemistryOpticsPhysicsPhotochromismPhotoacoustic and Ultrasonic ImagingNanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection