Acceptorless dehydrogenative synthesis of primary amides from alcohols and ammonia
Jie Luo, Quan‐Quan Zhou, Michael Montag, Yehoshoa Ben‐David, David Milstein
Abstract
liberation. Various aliphatic and aromatic primary amides were synthesized in high yields, with no observable N-containing byproducts. The selectivity of this system toward primary amide formation is rationalized through density functional theory (DFT) calculations, which show that dehydrogenation of the hemiaminal intermediate into primary amide is energetically favored over its dehydration into imine.
Topics & Concepts
Primary (astronomy)AmmoniaChemistryCombinatorial chemistryDehydrogenationOrganic chemistryCatalysisAstronomyPhysicsChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry