GDC-0980 (apitolisib) treatment with gemcitabine and/or cisplatin synergistically reduces cholangiocarcinoma cell growth by suppressing the PI3K/Akt/mTOR pathway
Dong Kee Jang, Yu Geon Lee, Young Chan Chae, Jun Kyu Lee, Woo Hyun Paik, Sang Hyub Lee, Yong‐Tae Kim, Ji Kon Ryu
Topics & Concepts
PI3K/AKT/mTOR pathwayGemcitabineCisplatinProtein kinase BCancer researchCell growthPharmacologyChemistryApoptosisMedicineChemotherapyInternal medicineBiochemistryCholangiocarcinoma and Gallbladder Cancer StudiesCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancer