Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions
Roberto del Río‐Rodríguez, Matthew T. Westwood, Marina Sicignano, Martin Juhl, José A. Fernández‐Salas, José Alemán, Andrew D. Smith
Abstract
a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.
Topics & Concepts
Enantioselective synthesisConjugateChemistryRadicalAmmoniumPhotocatalysisPolarCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisMathematicsAstronomyMathematical analysisPhysicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods