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Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways

Dongqiang Zhao, Yu Liu, Fengchao Yi, Xia Zhao, Kui Lu

2023European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

KRASHRASNeuroblastoma RAS viral oncogene homologCancer researchCancerMechanism of actionChemistryMutationGeneComputational biologyBiologyGeneticsIn vitroUbiquitin and proteasome pathwaysProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways | Litcius