Genetic Pathways Underlying Individual Differences in Regular Physical Activity
Eco J. C. de Geus
Abstract
Twin and family studies show a strong contribution of genetic factors to physical activity (PA) assessed by either self-report or accelerometers. PA heritability is around 43% across the lifespan. Genome-wide association studies have implied biological pathways related to exercise ability and enjoyment. A polygenic score based on genetic variants influencing PA could help improve the success of intervention programs.
Topics & Concepts
HeritabilityTwin studyPhysical activityGenome-wide association studyGenetic associationBiologyIntervention (counseling)PsychologyGeneticsMedicinePhysical medicine and rehabilitationSingle-nucleotide polymorphismGenotypeGenePsychiatryGenetics and Physical PerformanceObesity, Physical Activity, DietChildren's Physical and Motor Development