A triphasic biomimetic BMSC-loaded scaffold for osteochondral integrated regeneration in rabbits and pigs
Zhaoyi Wang, Wangbei Cao, Fanghui Wu, Xiurong Ke, Xinyu Wu, Tong Zhou, Jun Yang, Guojing Yang, Cheng Zhong, Zhongru Gou, Changyou Gao
Abstract
. The superficial cartilage showed good recovery and uniformity. The calcified cartilage layer (CCL) fibrous membrane was in favor of a better cartilage regeneration morphology, a continuous cartilage structure and less fibrocartilage tissue formation. The bone tissue grew into the material, while the CCL membrane limited bone overgrowth. The newly generated osteochondral tissues were well integrated with the surrounding tissues too.
Topics & Concepts
CartilageScaffoldRegeneration (biology)FibrocartilageBiomedical engineeringHyaline cartilagePerichondriumMaterials scienceAnatomyChemistryTissue engineeringBone tissueChondroitin sulfateStromal cellGlycosaminoglycanArticular cartilagePathologyOsteoarthritisCell biologyMedicineBiologyAlternative medicineBone Tissue Engineering MaterialsOsteoarthritis Treatment and MechanismsHydrogels: synthesis, properties, applications