CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Christopher G. Langendorf, Matthew T. O’Brien, Kevin R. W. Ngoei, Luke M. McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi X.Y. Ling, Toby A. Dite, Sandra Galić, Kim Loh, Michael W. Parker, Jonathan S. Oakhill, Bruce E. Kemp, John W. Scott
Abstract
) 14-3-3 consensus sites on CaMKK2 cooperate to bind 14-3-3 proteins. Our findings provide detailed molecular insights into how cAMP-PKA signaling inactivates CaMKK2 and reveals a pathway to inhibit CaMKK2 with potential for treating human diseases.
Topics & Concepts
Signal transducing adaptor proteinChemistryCell biologySignal transductionBiochemistryBiology14-3-3 protein interactionsUbiquitin and proteasome pathwaysProtein Kinase Regulation and GTPase Signaling