Research Progress into the Biological Functions of IFITM3
Qian Xie, Liangliang Wang, Xinzhong Liao, Bi Huang, Chuming Luo, Guancheng Liao, Lifang Yuan, Xuejie Liu, Huanle Luo, Yuelong Shu
Abstract
Interferon-induced transmembrane proteins (IFITMs) are upregulated by interferons. They are not only highly conserved in evolution but also structurally consistent and have almost identical structural domains and functional domains. They are all transmembrane proteins and have multiple heritable variations in genes. The IFITM protein family is closely related to a variety of biological functions, including antiviral immunity, tumor formation, bone metabolism, cell adhesion, differentiation, and intracellular signal transduction. The progress of the research on its structure and related functions, as represented by IFITM3, is reviewed.