Characterization, mechanism and <i>in vivo</i> validation of <i>Helicobacter pylori</i> antagonism by probiotics screened from infants’ feces and oral cavity
Junyi Li, Fei Peng, Hui Huang, Xiaoyan Xu, Qianqian Guan, Mingyong Xie, Tao Xiong
Abstract
. LAB also reduced IL-8 secretion, ultimately alleviating the inflammatory response of gastric mucosa. Whole genome sequencing (WGS) data showed that the NCUH062003 genome contained the secondary metabolite biosynthesis gene cluster T3PKS. Furthermore, NCUH062003 had a strong energy metabolism and substance transport capacity, and produced a small molecule heat stable peptide (SHSP, 4.1-6.5 kDa). Meanwhile, LAB proved to be safe through antibiotic susceptibility testing and CARD database comparisons.
Topics & Concepts
Helicobacter pyloriAntibioticsIn vivoChronic gastritisFecesIntestinal metaplasiaHelicobacterGastritisAntagonismGastroenterologyMedicineGut floraMechanism (biology)MicrobiologyInternal medicineImmunologyBiologyEpistemologyBiotechnologyReceptorPhilosophyHelicobacter pylori-related gastroenterology studiesMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disorders