Conformational fingerprinting of tau variants and strains by Raman spectroscopy
George Devitt, Anna Crisford, William J. Rice, Hilary A. Weismiller, Zhanyun Fan, Caitlin Commins, Bradley T. Hyman, Martin Margittai, Sumeet Mahajan, Amritpal Mudher
Abstract
We report that the physiochemical properties of the aggregation environment dictate the conformation of tau strains, which can be characterized and distinguished using Raman spectroscopy.
Topics & Concepts
Raman spectroscopyFibrilTau proteinChemistryConformational isomerismNeurodegenerationTauopathyProtein aggregationBiophysicsConformational ensemblesProtein foldingProtein structureBiochemistryBiologyMoleculeAlzheimer's diseaseMedicineDiseasePhysicsOrganic chemistryOpticsPathologyAlzheimer's disease research and treatmentsProtein Structure and DynamicsCholinesterase and Neurodegenerative Diseases