Multi-enzyme catalysed processes using purified and whole-cell biocatalysts towards a 1,3,4-substituted tetrahydroisoquinoline
Douglas Weber, Lucas de Souza Bastos, Margit Winkler, Yeke Ni, Abil E. Aliev, Helen C. Hailes, Dörte Rother
Abstract
NCS-A79I), leading to the formation of the target THIQ product with high HPLC yields (>90%, ic > 90%). As many of the educts applied are from renewable resources and a complex product with three chiral centers can be gained by only four highly selective steps, a very step- and atom efficient approach to stereoisomerically pure THIQ is shown.
Topics & Concepts
TetrahydroisoquinolineChemistryEnzymeCofactorBenzoic acidBiocatalysisSubstrate (aquarium)ChromatographyReductaseCatalysisStereochemistryBiochemistryReaction mechanismOceanographyGeologyEnzyme Catalysis and ImmobilizationSynthesis and Biological ActivityCarbohydrate Chemistry and Synthesis