Enhancing the yield and activity of defucosylated antibody produced by CHO-K1 cells using Cas13d-mediated multiplex gene targeting

Mei‐Wei Lin, Chih‐Che Shen, Yen-Ju Lin, Min‐Yuan Chou, Nam Ngoc Pham, Yi‐Hao Chang, Chin-Wei Chang, Jih Ru Hwu, Mai Thanh Thi Nguyen, Yu‐Chen Hu

2021Journal of the Taiwan Institute of Chemical Engineers10 citationsDOI

Topics & Concepts

FucosylationChinese hamster ovary cellAntibody-dependent cell-mediated cytotoxicityAntibodyGene knockdownChemistryMolecular biologyBiologyCytotoxicityCell biologyCell cultureBiochemistryGeneImmunologyIn vitroFucoseGeneticsGlycoproteinViral Infectious Diseases and Gene Expression in InsectsCRISPR and Genetic EngineeringMonoclonal and Polyclonal Antibodies Research