Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from<i>Fischerella ambigua</i>108b
Elke R. Duell, Tobias M. Milzarek, Mustafa El Omari, Luis Linares-Otoya, Till F. Schäberle, Gabrielle M. König, Tobias A. M. Gulder
Abstract
The biosynthetic pathway to the ambigols A–C from <italic>Fischerella ambigua</italic> 108b has been identified, cloned, heterologously expressed and functionally studied, including in-depth analysis of the biaryl coupling biochemistry<italic>in vivo</italic>and<italic>in vitro</italic>.
Topics & Concepts
Cloning (programming)ChemistryComputational biologyMolecular biologyBiologyComputer scienceProgramming languageToxic Organic Pollutants ImpactMicrobial bioremediation and biosurfactantsPesticide and Herbicide Environmental Studies