An easily available endoplasmic reticulum targeting near-infrared fluorescent probe for esterase imaging <i>in vitro</i> and <i>in vivo</i>
Chunbai Xiang, Jingjing Xiang, Yang Xing, Baode Zhu, Quanyi Mo, Lihua Zhou, Ping Gong
Abstract
Here, we report an easily available endoplasmic reticulum-targeting near-infrared fluorescent probe (ER-CE), which can detect esterase in the endoplasmic reticulum and monitor the changes in the esterase amount in tumors in mice in real time. These results indicate that ER-CE is expected to become a powerful analysis tool for the research of endoplasmic reticulum esterase-related diseases.
Topics & Concepts
Endoplasmic reticulumIn vivoEsteraseFluorescenceSTIM1Cell biologyIn vitroChemistryBiophysicsBiochemistryBiologyEnzymeBiotechnologyOpticsPhysicsEndoplasmic Reticulum Stress and DiseaseAdenosine and Purinergic SignalingCellular transport and secretion