Comprehensive multi-omics analysis of pyroptosis for optimizing neoadjuvant immunotherapy in patients with gastric cancer
Jia‐Bin Wang, You-Xin Gao, Yin‐Hua Ye, Qiao-Ling Zheng, Hua-You Luo, Shuanhu Wang, Tao Zhang, Qinwen Jin, Chao‐Hui Zheng, Ping Li, Jian‐Xian Lin, Qi‐Yue Chen, Long‐Long Cao, Yinghong Yang, Chang‐Ming Huang, Jian‐Wei Xie
Abstract
Our study demonstrated that pyroptosis activates immune processes in the tumor microenvironment. A low PRS correlates with enhanced infiltration of anti-tumor immune cells at the tumor site, increased pyroptotic activity, and improved patient outcomes. The constructed PRS can be used as an effective quantitative tool for pyroptosis analysis to guide more effective immunotherapeutic strategies for patients with GC.
Topics & Concepts
PyroptosisImmunotherapyImmune systemTumor microenvironmentMedicineCancer researchBiomarkerCancer immunotherapyOncologyImmunologyInflammationBiologyInflammasomeBiochemistryCancer Immunotherapy and BiomarkersInflammasome and immune disordersFerroptosis and cancer prognosis