Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of <i>pho1</i> Gene Expression
Bradley Benjamin, Angad Garg, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman
Abstract
Expression of the fission yeast phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate (IPP) signaling molecule 1,5-IP 8 . IP 8 dynamics are determined by Asp1, a bifunctional enzyme comprising N-terminal IPP 1-kinase and C-terminal IPP 1-pyrophosphatase domains that catalyze IP 8 synthesis and catabolism, respectively.
Topics & Concepts
PyrophosphateInositolPyrophosphataseYeastBiochemistryInositol phosphateChemistrySchizosaccharomyces pombeKinasePhosphofructokinase 2Inorganic pyrophosphataseIntracellularPyrophosphatasesEnzymeCell biologyBiologySaccharomyces cerevisiaeReceptorProtein Kinase Regulation and GTPase SignalingCellular transport and secretionATP Synthase and ATPases Research