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iNOS regulates activation of the NLRP3 inflammasome through the sGC/cGMP/PKG/TACE/TNF-α axis in response to cigarette smoke resulting in aortic endothelial pyroptosis and vascular dysfunction

Ke Liao, Dingyi Lv, Huilin Yu, Hong Chen, Suxin Luo

2021International Immunopharmacology32 citationsDOI

Topics & Concepts

PyroptosisEnosInflammasomeChemistryNitric oxide synthaseViability assayProinflammatory cytokinePharmacologyEndothelial dysfunctionNitric oxideInternal medicineMedicineInflammationApoptosisBiochemistryInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideInflammatory mediators and NSAID effects
iNOS regulates activation of the NLRP3 inflammasome through the sGC/cGMP/PKG/TACE/TNF-α axis in response to cigarette smoke resulting in aortic endothelial pyroptosis and vascular dysfunction | Litcius