Litcius/Paper detail

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons

Djuna von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching‐Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, Guillaume Leclerc, G. Menchaca, Gwyneth Welch, Agnese Graziosi, Noelle Leary, George Samaan, Manolis Kellis, Li‐Huei Tsai

2025Nature7 citationsDOIOpen Access PDF

Topics & Concepts

MitochondrionPhosphatidylcholineCell biologyBiologyTransporterLipid metabolismOxidative stressInduced pluripotent stem cellChemistryExcitotoxicityNeuronGene expressionCellMitochondrial DNANeurodegenerationBiochemistryMolecular biologyRegulation of gene expressionMembrane potentialGeneKnockout mouseProgrammed cell deathSecretionMitochondrial Function and PathologyPancreatic function and diabetesAdipose Tissue and Metabolism