Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis
Xing Huang, Zihe Wang, Shengzhong Hou, Chao Yue, Zhenlu Li, Weiming Hu, Huimin Lu
Abstract
animal model was constructed to determine the role of DSCAM-AS1 in tumor growth. Our results showed that DSCAM-AS1 was elevated in tumor tissues of pancreatic cancer patients and cell lines. DSCAM-AS1 knockdown efficiently inhibited PANC-1 cell proliferation, migration, and invasion and suppressed tumor growth. DSCAM-AS1 could promote PBX3 expression by sponging miR-136-5p, and its function in pancreatic cancer was partially mediated by the miR-136-5p/PBX3 axis. Overall, DSCAM-AS1 knockdown inhibits pancreatic cancer progression by modulating the miR-136-5p/PBX3 axis.
Topics & Concepts
Gene knockdownCancer researchCompeting endogenous RNAPancreatic cancerBiologyTumor progressionCell growthAntisense RNACancerCell cultureLong non-coding RNADownregulation and upregulationRNAGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerMicroRNA in disease regulation