Therapeutic targeting the oncogenic driver EWSR1::FLI1 in Ewing sarcoma through inhibition of the FACT complex
Jialin Mo, Kezhe Tan, Yu Dong, Wenjie Lu, Fang Liu, Yanqing Mei, Hongting Huang, Kewen Zhao, Zhibao Lv, Youqiong Ye, Yujie Tang
Topics & Concepts
BiologyEpigeneticsFLI1Transcription factorChromatinCancer researchEffectorCarcinogenesisCell biologyGeneticsGeneSarcoma Diagnosis and TreatmentProtein Degradation and InhibitorsGenomics and Chromatin Dynamics