Predictors of long-term recurrence and survival after resection of HBV-related hepatocellular carcinoma: the role of HBsAg.
I‐Cheng Lee, Hao‐Jan Lei, Gar‐Yang Chau, Yi‐Chen Yeh, Chi-Jung Wu, Chien‐Wei Su, Teh‐Ia Huo, Yee Chao, Han‐Chieh Lin, Ming‐Chih Hou, Yi‐Hsiang Huang
Abstract
(HR=2.720, P=0.013) and significant hepatic fibrosis (HR=2.509, P=0.039) were independent predictors of very late recurrence. HBsAg >50 IU/mL (HR=11.427, P=0.017), age >60 years (HR=2.688, P=0.006), albumin ≤3.5 g/dL (HR=4.739, P<0.001) and presence of cirrhosis (HR=2.781, P=0.006) were independent predictors of late mortality beyond 5 years. Combining these factors could well predict patients with minimal risk of long-term recurrence and mortality. In conclusion, tumor factors, liver function surrogate markers, metabolic factors and serum HBsAg levels play distinct roles in recurrence and survival at different time intervals after surgical resection for HBV-related HCC. Pre-operative HBsAg level is an important predictor of long-term recurrence and survival in patients with HBV-related HCC undergoing surgical resection.