Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome
Yiwen Fan, Jill Moser, Rianne M. Jongman, Theo Borghuis, Judith M. Vonk, Wim Timens, Matijs van Meurs, Janesh Pillay, Janette K. Burgess
Abstract
Our study revealed ECM protein compositional differences in lung parenchyma between stages of DAD. In advanced DAD, tissue density was higher, but collagen type III, type IV, and lumican were proportionally lower compared with early DAD. The organization of collagen type VI fibers was highly concentrated in advanced DAD. Our results indicate that both composition and organization of ECM were remodeled in advanced DAD, suggesting a role in manifesting acute respiratory distress syndrome.
Topics & Concepts
ARDSExtracellular matrixFibronectinLumicanLungPathologyDiffuse alveolar damageRespiratory distressPathophysiologyAcute respiratory distressMedicineBiologyCell biologyInternal medicineProteoglycanSurgeryDecorinTissue Engineering and Regenerative MedicineCardiac Fibrosis and RemodelingCardiac Structural Anomalies and Repair