Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants
Chin B. Eap, Gerhard Gründer, Pierre Baumann, Nicolas Ansermot, Andreas Conca, Emmanuelle Corruble, Séverine Crettol, Marja‐Liisa Dahl, José de León, C. Greiner, Oliver Howes, E. Kim, Rupert Lanzenberger, Jeffrey H. Meyer, R. Moessner, Hans Mulder, D Müller, Margareta Reis, Peter Riederer, Henricus G. Ruhé, Olav Spigset, Edoardo Spina, B. Stegman, Werner Steimer, Julia Stingl, H. Sinan Süzen, Hiroyuki Uchida, Stefan Unterecker, Frederik Vandenberghe, Christoph Hiemke
Abstract
To guide antidepressant drug therapy in everyday practice, there are multiple indications such as uncertain adherence, polypharmacy, nonresponse and/or adverse reactions under therapeutically recommended doses, where therapeutic drug monitoring and cytochrome P450 genotyping and/or phenotyping should be applied as valid tools of precision medicine.