Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1
Sergio Corrales-Guerrero, Tiantian Cui, Verónica Castro-Aceituno, Linlin Yang, Sindhu Nair, Haihua Feng, Monica Venere, Stephanie Yoon, T.A. DeWees, Changxian Shen, Terence M. Williams
Topics & Concepts
Synthetic lethalityDownregulation and upregulationRadioresistanceCancer researchRibonucleotide reductaseGene silencingDNA repairChemistryMedicineRadiation therapyDNABiochemistryGeneProtein subunitInternal medicineGlioma Diagnosis and TreatmentMetal-Catalyzed Oxygenation MechanismsCancer, Hypoxia, and Metabolism