Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles
Irene Beusch, Beiduo Rao, Michael Studer, Tetiana Luhovska, Viktorija Šukytė, Susan Lei, Juan A. Osés-Prieto, Em SeGraves, Alma L. Burlingame, Stefanie Jonas, Hiten D. Madhani
Topics & Concepts
SpliceosomeBiologysnRNPRNA splicingMutantMutagenesisCRISPRGeneticsComputational biologyCell biologyRNAGeneRNA Research and SplicingRNA and protein synthesis mechanismsCRISPR and Genetic Engineering