Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis
Eman Maher Zahran, Soad A. Mohamad, Mohamed M. Elsayed, Mohamed Hisham, Sherif A. Maher, Usama Ramadan Abdelmohsen, Mahmoud A. Elrehany, Samar Yehia Desoukey, Mohamed Salah Kamel
Abstract
Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction.
Topics & Concepts
OsteoarthritisInflammationMatrix metalloproteinaseNF-κBJoint diseaseUrsolic acidNFKB1PharmacologyInfiltration (HVAC)CartilageChemistryMedicineInternal medicinePathologyTranscription factorBiochemistryAnatomyGeneMaterials scienceComposite materialChromatographyAlternative medicineNatural product bioactivities and synthesisRheumatoid Arthritis Research and TherapiesBone Metabolism and Diseases