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Irbesartan suppresses lipopolysaccharide (LPS)-induced blood–brain barrier (BBB) dysfunction by inhibiting the activation of MLCK/MLC

Qixia Yang, Juanjuan Yu, Hao Qin, Long Liu, Chao Di, Qiang Zhuang, Hang Yin

2021International Immunopharmacology23 citationsDOI

Topics & Concepts

IrbesartanOccludinBlood–brain barrierTight junctionPharmacologyLipopolysaccharideCell biologyMedicineChemistryEndocrinologyBiologyCentral nervous systemBlood pressureBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsDrug Transport and Resistance Mechanisms
Irbesartan suppresses lipopolysaccharide (LPS)-induced blood–brain barrier (BBB) dysfunction by inhibiting the activation of MLCK/MLC | Litcius