Differential prognostic impact of cytopenic phenotype in prefibrotic vs overt primary myelofibrosis
Giacomo Coltro, Francesco Mannelli, Giuseppe Gaetano Loscocco, Carmela Mannarelli, Giada Rotunno, Chiara Maccari, Fabiana Pancani, Alessandro Atanasio, Alessandro M. Vannucchi, Paola Guglielmelli
Abstract
Cytopenias are frequent and distinctive features of primary myelofibrosis (PMF). Anemia is the most common, has consistently been associated with shortened survival, and is an integral component of prognostic models (IPSS, DIPSS/-plus MIPSS70/-plus) [ 1 , 2 , 3 , 4 ]. Albeit less frequent, also thrombocytopenia (defined as a platelet count <100 × 10 9 /L) was included in the DIPSS-plus and MIPSS70/-plus scores as independent predictor of reduced survival [ 3 , 4 , 5 , 6 , 7 ]. Conversely, leukopenia is the least frequent and has been inconsistently associated with inferior survival [ 8 , 9 , 10 ].