SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
Daniel M. Altmann, Rosemary J. Boyton
Abstract
In efforts to synthesize a clear understanding of SARS-CoV-2 protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild and severe COVID-19. Defining CD4 and CD8 effector functions in protection is important considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.
Topics & Concepts
ImmunityImmunologyCytokineBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Function (biology)Coronavirus disease 2019 (COVID-19)AntigenCD82019-20 coronavirus outbreakVirologyT cellCellular immunityImmune systemCell biologyMedicineDiseasePathologyOutbreakInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19