Ruthenium-catalyzed acceptorless dehydrogenative coupling of amino alcohols and ynones to access 3-acylpyrroles
Mingshi Pan, Xiabin Wang, Yixin Tong, Xiaodong Qiu, Xiaobao Zeng, Biao Xiong
Abstract
ruthenium-catalyzed acceptorless dehydrogenative coupling has been demonstrated. This developed methodology proceeds in an atom- and step-economic fashion together with the merits of broad substrate scope, operational simplicity, and water and hydrogen gas as the sole by-products, which provides an alternative and sustainable way to access functionalized pyrroles. Further, this method was applied to the rapid synthesis of the COX-1/COX-2 inhibitor and boron dipyrromethene derivative successfully.
Topics & Concepts
RutheniumCatalysisCombinatorial chemistryChemistrySubstrate (aquarium)Scope (computer science)Atom economyBoronDerivative (finance)Organic chemistryComputer scienceBusinessOceanographyFinanceGeologyProgramming languageAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions